Driving across long distances on difficult terrain in a rickshaw is an extremely dangerous thing to do, which can result in severe injury and even death.
The rickshaw you will be driving in the Rickshaw Run will be totally different to anything you may be used to driving. They are difficult to steer and can be unsteady to drive. They are not suited to driving long distances on varied terrain and are generally unreliable meaning they are likely to break down, and compared to other possible forms of transport put you at higher risk of being involved in an accident.
Altitude sickness can cause death directly or indirectly by affecting driving behaviour. You'll reach heights of over 5000m high with average over 3000m. Altitude sickness can take effect as low as 1500m, so do take time to acclimatize properly.
The Rickshaw Run will be a gruelling journey in an uncomfortable form of transport across many hundreds of kilometres.
This means that it may be the case that you suffer short and long term physical effects that cannot be predicted. The nature of the adventure means that if you are involved in an accident whilst driving your rickshaw from the start to the finish line, then the nearest medical assistance may be many hours and miles away from you. If you are injured in a way that requires specialist attention, it may be the case that the region that you are in does not have adequate medical facilities to treat your injuries. On previous Adventurists' adventures, severely injured individuals on Adventurists' teams have had to be evacuated out of their location to medical centres in alternative countries.
Don't underestimate how dangerous this adventure is.